Some regions of the world have no route — no boat, no teleport, no path over land. The only way in is the region's Runic Scroll, dropped by monsters within a 40-rank window around the region's average (the stronger the monster inside that window, the higher the chance).
Use: only inside a protection zone (temple or depot) — the same rule as logging out. On arrival you receive a return scroll that takes you back to your home temple (also consumable).
